RISK FACTORS OF REALIZATION AND CLINICAL AND LABORATORY FEATURES OF THE COURSE OF PROLONGED NEONATAL PATHOLOGICAL JAUNDICE IN PREMATURE NEWBORNS

Pathological jaundice in newborns is the leading cause of neonatal morbidity and mortality. The purpose of our study was to identify and rank risk factors and clinical and laboratory features of the course of prolonged neonatal pathological jaundice in premature infants. The object of the study were newborns with pathological hyperbilirubinemia: premature newborns (198 children) and full-term newborns (205 children). The severity of the condition was assessed by the level of indirect hyperbilirubinemia, clinical manifestations and assessments on the Kramer, AVPU and Glasgow scales. It has been established that there are many evidently significant risk factors for the development of prolonged neonatal pathological hyperbilirubinemia, more pronounced in premature infants. Premature infants have an atypical clinical picture, a more severe prolonged course with high indirect hyperbilirubinemia (p<0.05).