PATHOGENESIS OF APLASTIC ANEMIA (LITERATURE REVIEW)

Aplastic anemia is a rare and life-threatening bone marrow insufficiency that leads to peripheral blood cytopenia and decreased proliferation of hematopoietic bone marrow cells. The symptoms are similar to myelofibrosis, myelodysplastic syndromes and acute myeloid leukemia, which makes it difficult to diagnose this disease. The pathogenesis of aplastic anemia is complex, and its mechanism needs to be deciphered on an individual basis. This review summarizes several contributions made in recent years in an attempt to understand the pathogenesis of aplastic anemia, which may be useful for the development of personalized treatments for this disease