Guided programmed drug treatment of acute destructive pancreatitis

Background. Acute destructive pancreatitis is a condition in which a complex mechanism of development occurs, including several stages. Complications resulting from inflammation in the pancreas can include pancreatic necrotizing infection, peritonitis, abscesses, and systemic inflammatory responses, which can lead to multiple organ failure and even death. Understanding this developmental mechanism highlights the importance of timely diagnosis and effective treatment to prevent severe complications and improve the prognosis for patients. Purpose of the study. The main goal was to find out whether a combination of drugs can improve outcomes in acute destructive pancreatitis. Materials and research methods: a program for the administration of drugs directly into the target organ by catheterization of the splenic artery has been developed. The results of the treatment of 144 patients with acute destructive pancreatitis who were admitted to the surgical department of the Astana City Multidisciplinary Hospital No. 2 in 2020-2023 were analyzed. The age of the patients is from 30 to 63 years. There was a predominance of the age group of the working age period from 41 to 63 years - (81.9%). There were 86 men (59.7%) and 58 women (40.3%). Study results. The absence of septic complications was noted in 42 out of 72 patients in the main group and in 36 out of 72 patients in the control group. Urgent surgical intervention was required in 7 out of 72 patients in the main group and in 24 out of 72 patients in the control group. The mortality rate was 4 out of 72 in the main group and 8 out of 72 in the control group. The average length of hospital stay was shorter in patients of the main group. Conclusion: the study showed that the combination of drugs chosen by us is more effective in preventing septic complications and reducing mortality in ADP than intravenous therapy