Prevention of postoperative pain syndrome after laparoscopic cholecystectomy

Purpose of the study: to evaluate the effectiveness of the method of preemptive analgesia on the degree of postoperative pain syndrome in patients after laparoscopic cholecystectomy. Material and methods: a single-center randomized prospective study was conducted, which included 109 patients with acute calculous cholecystitis. All patients were divided into 2 groups: the main group (n=56), in which the developed method of preemptive analgesia was used, and the control group (n=53), where preemptive analgesia was not performed. The intensity of postoperative pain syndrome was recorded at 2, 6, 12, 24, 36 and 48 hours after surgery. Results and discussion. Postoperative pain syndrome was significantly (p<0.001) minimal in the group where preemptive analgesia was used. A significant reduction in postoperative pain syndrome was recorded 12 hours after surgery in all groups. The International Association for the Study of Pain indicates the adequacy of the degree of analgesia after surgery for pain levels less than 3 mm on VAS, which was achieved in the first group within 12 hours after laparoscopic cholecystectomy. In the second group, VAS values of less than 3 mm were recorded 48 hours after surgery. Conclusions. The developed method of intraoperative preemptive analgesia during laparoscopic cholecystectomy allows us to reliably minimize the degree of postoperative pain syndrome, and reduce the frequency of postoperative analgesia and abandon opioid analgesia