Features of the distribution of highly sensitive troponin I concentration among residents of the Chui region of the Kyrgyz Republic, taking into account gender and age

The aim of the study: was to investigate the distribution of the concentration of highly sensitive troponin I (hsTnI) in a representative sample of residents of the Chui region of the Kyrgyz Republic, taking into account gender and age. Material and methods. The material was a representative sample of the population aged 18-65 years in the Kyrgyz Republic (n = 1276, including 529 men and 747 women). An analysis of the distribution of hsTnI levels in the population was carried out taking into account gender and age. The level of hsTnI in blood serum samples was measured by immunochemiluminescent assay with microparticles, using Architect Stat High Sensitive Troponin I reagents (Abbott, USA) on an automated analyzer Architect i2000SR (Abbott, USA). The level of statistical significance was taken to be 0.05. Results. The median hsTnI concentration in the sample was 1.2 pg/ml, the interquartile range was (0.6; 2.0) pg/ml. The 99th percentile was 19.7 pg/ml. hsTnI levels were significantly higher in men - 1.5 (0.8; 2.3) pg/ml, than in women - 1.0 (0.4; 1.8) pg/ml, (p = 0.009). The relationship between hsTnI concentration and age was characteristic of both men (r = 0.13; p = 0.002) and women (r = 0.16; p<0.001). Despite the lower initial values of hsTnI concentration, the rate of its increase with age was higher in women. A detailed comparative analysis of the dynamics of hsTnI concentration in different age groups in men and women was carried out. Conclusion. The revealed gender differences in the distribution of hsTnI concentration and its age dynamics must be taken into account when determining the threshold levels of this biomarker