Osteoarthritis of knee joint: Modern possibilities of local pathogenic therapy

Osteoarthritis is the most widespread disease of the musculoskeletal system, which leads to disability of patients and the need for joint replacement. Until now, the problem of effective local therapy remains a difficult problem in the treatment of osteoarthritis. The purpose of this work was to study the effectiveness of various clinical algorithms for the use of a linear series of biopolymer microheterogenic collagen-containing hydrogel Sphero®GEL in the treatment of various structural phenotypes of osteoarthritis in real clinical practice. The article presents data on the results of local therapy using bioimplant Sphero®GEL in 937 patients with various structural phenotypes of osteoarthritis, the effectiveness of therapy was evaluated using standardized indices VAS, WOMAC (pain, stiffness, functionality). The dynamics of structural changes was assessed according to ultrasound examination data. The data obtained indicate the effectiveness and safety of bioimplant Sphero®GEL in the treatment of various structural phenotypes of osteoarthritis