Possibilities of adjuvant intravesical drug therapy in noninvasive muscular bladder cancer (literature review)

Noninvasive musculoskeletal bladder cancer remains one of the most common diseases in the structure of oncourological diseases, ranking 7th in the world. According to statistics, the number of detected cases is increasing every year. In 75% of cases, according to the literature, this is noninvasive muscular bladder cancer. Timely diagnosis makes it possible to avoid minimally invasive treatment methods, such as transurethral resection or planar resection with mandatory further adjuvant intravesical drug therapy. Currently, the following types are used: Mitomycin C, Doxorubicin, BCG therapy, the most effective of which is BCG therapy, followed by Mitomycin C and Doxorubicin.  Also, some authors note the high effectiveness of intravesical chemotherapy in combination with local hyperthermia. Given the acute deficiency of BCG, Mitomycin C, the only available cytostatic agent is Doxorubicin. An alternative is to conduct intravesical chemotherapy with Cisplatin and Gemcitabine, which have long been used for invasive bladder cancer. However, further research is required to confirm the effectiveness of these drugs in non-invasive muscular bladder cancer. Thus, these medicines can serve as an alternative in an era of shortage of recommended drugs