Abstract
Osteoporosis is a progressive disease characterised by a decrease in bone mineral density, increasing bone fragility and risk of fractures. The study aimed to assess prevalence of osteoporosis and identify associated risk factors among postmenopausal women in Bishkek (Kyrgyz Republic). Study included 470 postmenopausal women who had lived in Bishkek (Kyrgyz Republic) for at least 5 years, including residents of Bishkek social care home (a residential care home for elderly). Age of participants ranged from 45 to 89 years, with a mean age of 60.1 ± 14.03 (95% CI 51.49-70.18). All participants were examined upon admission to Multidisciplinary Clinical Hospital No. 2 in Bishkek from July 2023 to August 2024. In postmenopausal women, prevalence of osteoporosis was 20.8%, osteopenic syndrome – 43.0% and normal bone mineral density – 36.2%. Thus, participants with a longer duration of menopause (more than 10 years) and concomitant type 2 diabetes mellitus had a higher prevalence of osteoporosis (p < 0.05). Furthermore, participants with a family history of symptoms associated with osteoporosis and bone fractures, as well as with personal history of bone fractures, also had higher prevalence of osteoporosis (p < 0.05). Smoking had a negative impact on bone health (p < 0.026). Overall prevalence of osteoporosis among postmenopausal women was 20.8%, and osteopenia was 43.0%. Raising awareness and encouraging lifestyle changes may help reduce risk and burden of osteoporosis among women in this age group
Keywords
bone mineral density; ultrasonic densitometry; osteoporosis; women; post-menopauseSuggested citation
References
- Xiao PL, Cui AY, Hsu C-J, Peng R, Jiang N, Xu XH, et al. Global, regional prevalence, and risk factors of osteoporosis according to the World Health Organization diagnostic criteria: A systematic review and meta-analysis. Osteoporos Int. 2022;33(10):2137–53. DOI: 10.1007/s00198-022-06454-3
- Khan AA, Slart RHJA, Ali DS, Bock O, Carey JJ, Camacho P, et al. Osteoporotic fractures: Diagnosis, evaluation, and significance from the International Working Group on DXA best practices. Mayo Clin Proc. 2024;99(7):1127–41. DOI: 10.1016/j.mayocp.2024.01.011
- Yu JS, Krishna NG, Fox MG, Blankenbaker DG, Frick MA, Jawetz ST, et al. ACR Appropriateness criteria® osteoporosis and bone mineral density: 2022 update. J Am Coll Radiol. 2022;19(11):417–32. DOI: 10.1016/j. jacr.2022.09.007
- Aibar-Almazán A, Voltes-Martínez A, Castellote-Caballero Y, Afanador-Restrepo DF, Carcelén-Fraile MDC, López-Ruiz E. Current status of the diagnosis and management of osteoporosis. Int J Mol Sci. 2022;23(16):9465. DOI: 10.3390/ijms23169465
- LeBoff MS, Greenspan SL, Insogna KL, Lewiecki EM, Saag KG, Singer AJ, et al. The clinician’s guide to prevention and treatment of osteoporosis. Osteoporos Int. 2022;33(10):2049–102. DOI: 10.1007/s00198-021-05900-y
- Poçan AG, Sönmezer M, Topal K, Aslan B, Gereklioğlu Ç, Sönmezer M. Investigation of the risk factors associated with osteoporosis in postmenopausal women. J Turk Ger Gynecol Assoc. 2023;24(4):235–40. DOI: 10.4274/ jtgga.galenos.2023.2023-7-9
- Imanalieva FE, Tagaev TJ, Marishbek E, Mamatov SM. Bone mineral density measured by ultrasound densitometry in adult population of the Kyrgyz Republic. Clin Gerontol. 2022;28(5–6):63–8. DOI: 10.26347/16072499202205-06063-068
- Tagaev TJ, Imanalieva FE, Mamatov SM, Marishbek E, Tagaeva BT. Prevalence of osteopenic syndrome and osteoporosis among residents of the older age group of Kyrgyzstan. Acta Biomed Sci. 2022;7(4):130–7. DOI: 10.29413/ABS.2022-7.4.16
- World Medical Association. World medical association declaration of Helsinki: Ethical principles for medical research involving human participants. JAMA. 2025;333(1):71–4. DOI: 10.1001/jama.2024.21972
- Woodson GC. Risk factors for osteoporosis in postmenopausal African-American women. Curr Med Res Opin. 2004;20(10):1681–7. DOI: 10.1185/030079904X3285
- Bener A, Saleh NM. Low vitamin D and bone mineral density with depressive symptoms burden in menopausal and postmenopausal women. J Midlife Health. 2015;6(3):108–14. DOI: 10.4103/0976-7800.165590
- Gupta R, Al-Saeed O, Azizieh F, Albusairi A, Gupta P, Mohammed A. Evaluation of bone mineral density in postmenopausal women in Kuwait. J Clin Densitom. 2012;15(2):211–6. DOI: 10.1016/j.jocd.2011.10.006
- Tian L, Yang R, Wei L, Liu J, Yang Y, Shao F, et al. Prevalence of osteoporosis and related lifestyle and metabolic factors of postmenopausal women and elderly men: A cross-sectional study in Gansu province, Northwestern China. Medicine (Baltimore). 2017;96(43):e8294. DOI: 10.1097/MD.0000000000008294
- Tenenhouse A, Joseph L, Kreiger N, Poliquin S, Murray TM, Blondeau L, et al. Estimation of the prevalence of low bone density in Canadian women and men using a population-specific DXA reference standard: The Canadian Multicentre Osteoporosis Study (CaMos). Osteoporos Int. 2000;11(10):897–904. DOI: 10.1007/ s001980070050
- Adewole OA, Idowu SO, Shoga MO, Kayode MO, Adelowo OO. Frequency of osteoporosis in Black Nigerian women aged 50 and above with degenerative musculoskeletal diseases and fractures. West Afr J Med. 2021;38(4):342–6.
- Kanis JA, Cooper C, Rizzoli R, Reginster JY. European guidance for the diagnosis and management of osteoporosis in postmenopausal women. Osteoporos Int. 2019;30(1):801. DOI: 10.1007/s00198-018-4704-5
- Sharma S, Khandelwal S. Effective risk assessment tools for osteoporosis in the Indian menopausal female. J Midlife Health. 2010;1(2):79–85. DOI: 10.4103/0976-7800.76217
- Nikose S, Singh P, Khan S, Arora M, Taywade S, Gudhe M, et al. Prevalence of osteoporosis in female population in rural central India [by calcaneal ultrasound]. J Womens Health Care. 2015;4(5):1000262. DOI: 10.4172/21670420.1000262
- Salari N, Ghasemi H, Mohammadi L, Behzadi MH, Rabieenia E, Shohaimi S, et al. The global prevalence of osteoporosis in the world: A comprehensive systematic review and meta-analysis. J Orthop Surg Res. 2021;16:609. DOI: 10.1186/s13018-021-02772-0
- Inoue T, Maeda K, Satake S, Matsui Y, Arai H. Osteosarcopenia, the co-existence of osteoporosis and sarcopenia, is associated with social frailty in older adults. Aging Clin Exp Res. 2022;34:535–43. DOI: 10.1007/s40520021-01968-y
- Zhou P, Zhang H, Nie Y, Zhang Y, Wang Y. Advances in the research field of osteoporosis in cold areas. Frigid Zone Med. 2022;2(1):1–9. DOI: 10.2478/fzm-2022-0001