Von Willebrand disease in Central Asia: How can we overcome it? (literature review)

Von Willebrand disease (VWD) is a genetic bleeding disorder related to quantitative and/or qualitative abnormalities of the Von Willebrand factor (VWF). This blood disorder, which often undergoes both underdiagnosis and overdiagnosis, is frequently misdiagnosed, resulting in prevented suffering for patients and increasing the burden on the healthcare system. This complex problem is driven by the diversity and pattern of the von Willebrand factor (VWF) and related anomalies, as well as the inevitable need to integrate robust and laboratory data to arrive at an accurate diagnosis, especially in the Central Asian regions. Misdiagnosis of VWD can indeed have serious consequences, potentially leading to increased morbidity and mortality in patients. Overdiagnosis can lead to unnecessary diagnoses and also potentially expose patients to increased thrombotic risk during therapy. Despite this, VWD is often being misdiagnosed all around the globe. This review will cover the problems faced during the diagnosis of VWD from the 19th century to the present day and suggest how to improve the situation