Some indicators of the immune system in animals not adapted to the high-mountain conditions with tubular bone fractures

The goal of this research is the study of cell immunity features for traumas in high mountain regions at different period of stay in adapted and unadapted to the high mountain regions animals. We studied one hundred and forty white laboratory rats of both gender at a height of 3200 meters above sea level in high mountain regions of Too-Ashuu base. By the end of the experiment, the concentration of main lymphocyte subpopulations in the studied animals of the control group returned to the initial values, while in the animals of the main group these data remain significantly increased. It was found that in unadapted to the high mountain region animals the dynamics of main lymphocyte subpopulations for traumas had multidirectional character. It was also determined that the complex effect of high mountain factors and traumas have an impact on the cell-mediated response, causing an increase or decrease the concentration of one or another lymphocyte subpopulations. In turn, this indicated the multidirectional suppressive or stimulating effect of abovementioned factors on the immune system. Differences, found out under study in the composition of main lymphocyte subpopulations indicate the irregular its involvement in the osteanagenesis regeneration in the high mountain regions on the different stages of experiment on the ground of modeled bone fractures