Abstract
Acute paraproctitis is a clinically significant suppurative inflammatory lesion of the pararectal tissue that requires timely diagnosis, adequate surgical drainage, and follow-up because of the risk of recurrence and anal fistula formation. The purpose of this study was to summarise current literature on the aetiology, pathogenesis, classification, diagnosis, surgical treatment, and postoperative management of patients with acute paraproctitis. A narrative literature review with elements of comparative analysis was carried out. The review established that acute paraproctitis most often develops as a manifestation of cryptoglandular infection, with polymicrobial flora and spread of pus into the perianal, intersphincteric, ischioanal, or supralevator space. For a typical superficial abscess, clinical inspection and digital rectal examination are sufficient, whereas recurrent, deep, and Crohn-associated forms require magnetic resonance imaging or endoanal ultrasonography. Timely incision and drainage remain the basic method of treatment. Primary fistulotomy was justified only for a clearly verified low fistula, whereas complex forms required a staged approach, with possible use of a draining seton. According to the reviewed sources, the rate of fistula formation after drainage was 23.0-33.9%, and, in a randomised study, omission of packing reduced pain from 38.2 to 28.2 points without a statistically significant increase in fistula or recurrence rates. Antibiotic therapy had selective value in systemic infection, cellulitis, immunosuppression, or diabetes mellitus. The optimal management strategy should be stratified according to anatomical form, fistula risk, systemic manifestations, and comorbid background. The practical significance of the study lies in substantiating a stratified algorithm for managing patients with acute paraproctitis, which differentiates simple and complex forms of the disease, identifies the need for imaging, antibacterial therapy, and staged surgical treatment in due time, and accounts for the risk of recurrence and anal fistula formation
Keywords
anorectal abscess; cryptoglandular infection; anal fistula; drainage; seton; postoperative follow-upSuggested citation
References
- McQuaid KR. Anorectal infections. In: Papadakis MA, Rabow MW, McQuaid KR, Nadler PL, Price EL, editors. Current medical diagnosis & treatment 2024. New York: McGraw Hill; 2024. 17–41.
- Qi C, Li J. Diagnostic performance of three-dimensional endoanal ultrasound compared with MRI in anal fistula: A systematic review and meta-analysis. Acad Radiol. 2026;33(5):1978–91. DOI: 10.1016/j.acra.2026.01.058
- Hosokawa T. Perianal sonographic approach to fistula-in-ano and perianal abscesses: A pictorial review. Cureus. 2026;18(2):e103963. DOI: 10.7759/cureus.103963
- Kussainova A, Bulegenov T, Dzhusupov K, Kuderbayev M, Kusainov A, Ashubayeva A, et al. Clinical and organizational aspects of paraproctitis management in the Abay region of Kazakhstan. Georgian Med News. 2025;10(367):131–6.
- Karacan E, Yılmaz EM. Treatment of the fistula tract with laser ablation in high anal fistula. J Clin Med Kaz. 2022;19(6):43–5. DOI: 10.23950/jcmk/12685
- Turner GA, Tham N, Chandra R, Read DJ, Chittleborough TJ, McCormick JJ, et al. Management of acute perianal abscess: Is surgeon specialization associated with improved outcomes? ANZ J Surg. 2024;94(5):938–44. DOI: 10.1111/ans.18836
- Casas MA, Correa Roa C, Schlottmann F, Bun ME, Rotholtz NA. Surgical outcomes of emergent perianal abscess treatment: Does colorectal specialization matter? J Surg Res. 2025;313:351–5. DOI: 10.1016/j.jss.2025.06.051
- Hu J, Li X, Zhang Y, Wang H, Chen L, Liu Q. Clinical application of the intersphincteric approach with internal incision combined with counter-drainage for deep perianal abscess. BMC Gastroenterol. 2025;25:94. DOI: 10.1186/s12876-025-03703-7
- Ghahramani L, Minaie MR, Arasteh P, Hosseini SV, Izadpanah A, Bananzadeh AM, et al. Antibiotic therapy for prevention of fistula in-ano after incision and drainage of simple perianal abscess: A randomized single blind clinical trial. Surgery. 2017;162(5):1017–25. DOI: 10.1016/j.surg.2017.07.001
- Kim HC, Simianu VV. Contemporary management of anorectal fistula. Surg Open Sci. 2024;17:40–3. DOI: 10.1016/j.sopen.2023.12.005
- Gaertner WB, Burgess PL, Davids JS, Lightner AL, Shogan BD, Sun MY, et al. The American society of colon and rectal surgeons clinical practice guidelines for the management of anorectal abscess, fistula-in-ano, and rectovaginal fistula. Dis Colon Rectum. 2022;65(8):964–85. DOI: 10.1097/DCR.0000000000002473
- Tarasconi A, Perrone G, Davies J, Coimbra R, Moore EE, Azzaroli F, et al. Anorectal emergencies: WSES-AAST guidelines. World J Emerg Surg. 2021;16:48. DOI: 10.1186/s13017-021-00384-x
- Kata A, Abelson JS. Anorectal abscess. Clin Colon Rectal Surg. 2024;37(6):368–75. DOI: 10.1055/s-0043-1777451
- Polyzou E, Gavatha M, Papageorgiou D, Mulita F, Akinosoglou K. Perianal abscesses. In: Vannelli A, editor. Diseases of the rectum and anus - a concise guide coloproctology. London: IntechOpen; 2025. DOI: 10.5772/intechopen.1010035
- Amato A, Bottini C, De Nardi P, Giamundo P, Lauretta A, Realis Luc A, et al. Evaluation and management of perianal abscess and anal fistula: SICCR position statement. Tech Coloproctol. 2020;24(2):127–43. DOI: 10.1007/s10151-019-02144-1
- Conner JN, Eren S, Tuma F. Perianal abscess. In: StatPearls. Treasure island. Tampa: StatPearls Publishing; 2023.
- Anand E, Pelly T, Joshi S, Shakweh E, Hanna LN, Hart A, et al. Current practice and innovations in diagnosing perianal fistulizing Crohn’s disease (pfCD): A narrative review. Tech Coloproctol. 2025;29(1):102. DOI: 10.1007/s10151-025-03122-6
- Habeeb H, Chen L, De Kock I, Kutaiba N, Vasudevan A, Srinivasan AR. Imaging in perianal fistulising Crohn’s disease: A practical guide for clinicians. World J Gastroenterol. 2025;31(34):110611. DOI: 10.3748/wjg.v31.i34.110611
- Kawecki MP, Kruk AM, Drążyk M, Domagała Z, Woźniak S. Exploring perianal fistulas: Insights into biochemical mechanisms, diagnostics and emerging therapeutic directions. Diagnostics. 2025;16(1):10. DOI: 10.3390/gastroent16010010
- Kumar S, Chaudhary RK, Shah SS, Kumar D, Nepal P, Ojili V. Current update on the role of endoanal ultrasound: A primer for radiologists. Abdom Radiol. 2024;49:2873–90. DOI: 10.1007/s00261-024-04300-0
- Barbu LA, Vasile L, Cercelaru L, Vîlcea ID, Șurlin V, Mogoantă SȘ, et al. Fused ischiorectal phlegmon with pre- and retroperitoneal extension: A case report and literature review. J Clin Med. 2025;14(14):4959. DOI: 10.3390/jcm14144959
- Reza L, Gottgens K, Kleijnen J, Breukink S, Ambe PC, Aigner F, et al. European society of coloproctology: Guidelines for diagnosis and treatment of cryptoglandular anal fistula. Colorectal Dis. 2024;26(1):145–96. DOI: 10.1111/codi.16741
- Erol T, Mentes B, Bayri H, Osmanov I, Leventoglu S, Yildiz A, et al. Preventing the recurrence of acute anorectal abscesses utilizing a loose seton: A pilot study. Pan Afr Med J. 2020;35:18. DOI: 10.11604/pamj.2020.35.18.21029
- Mocanu V, Dang JT, Ladak F, Tian C, Wang H, Birch DW, et al. Antibiotic use in prevention of anal fistulas following incision and drainage of anorectal abscesses: A systematic review and meta-analysis. Am J Surg. 2019;217(5):910–7. DOI: 10.1016/j.amjsurg.2019.01.015
- Van Oostendorp JY, Dekker L, van Dieren S, Bemelman WA, Buskens CJ, Gecse KB. Antibiotic Treatment foLlowing surgical drAinage of perianal abScess (ATLAS): Protocol for a multicentre, double-blind, placebo-controlled, randomised trial. BMJ Open. 2022;12(11):e067970. DOI: 10.1136/bmjopen-2022-067970
- Alabbad J, Almutairi S, Alsabagha N, Alhamly H, Alnaqi F. Associations between adjuvant antibiotic therapy and fistula formation after incision and drainage of anorectal abscesses: Results from a retrospective cohort study. Tech Coloproctol. 2026;30:24. DOI: 10.1007/s10151-025-03264-7
- Newton K, Dumville J, Briggs M, Law J, Martin J, Pearce L, et al. Postoperative packing of perianal abscess cavities (PPAC2): Randomized clinical trial. Br J Surg. 2022;109(10):951–7. DOI: 10.1093/bjs/znac225
- Hasan ZAIY, Mohamed B, AlSayegh R, AlMarzooq R. Incidence of anal fistula after pyogenic perianal abscess drainage in Kingdom of Bahrain. Ann Coloproctol. 2023;39(1):27–33. DOI: 10.3393/ac.2020.00962.0137
- Busbait SA. Recurrence rate and postoperative fistula formation: A retrospective analysis of surgically managed cases of anorectal abscess. Qatar Med J. 2025;2025(4):101. DOI: 10.5339/qmj.2025.101
- Fang F, Wen L. Multifactorial analysis of postoperative recurrence of anal fistula: A retrospective study. J Multidiscip Healthc. 2025;18:6015–24. DOI: 10.2147/JMDH.S537028
- Shehi E, Andrea G, Biberaj P, Dogjani A. Challenges in management of Fournier’s gangrene after the perianal abscess: A case report and review of literature. Open Access Maced J Med Sci. 2024;12(4):483–8. DOI: 10.3889/oamjms.2024.11964
- Zhang H, Gao X, Qu Y, Chen J, Liu H. The association between diabetes mellitus and perianal abscess: A meta-analysis. Diabetes Metab Syndr Obes. 2025;18:4449–63. DOI: 10.2147/DMSO.S543521
- Shevchuk IM, Novitsky OV, Shapoval AL, Sadovyi IY, Sverstyuk AS, Snizhko SS. Using ultrasound diagnostics and magnetic resonance tomography in surgical treatment of complicated forms of acute paraproctitis. World Med Biol. 2022;18(80):183–8. DOI: 10.26724/2079-8334-2022-2-80-183-188
- Sanchez-Haro E, Molinos S, Troya J, Tapiolas I, Vela S, Cardona PJ, et al. Bacteriology of anorectal abscess and anal fistula: A systematic review of the literature. Surg Infect. 2025;26(9):707–19. DOI: 10.1177/10962964251369451
- Polaino Moreno V, Caballero-Bermejo AF, Artés Caselles M, Serrano González J, Remírez Arriaga X, González Alcolea N, et al. Efficacy of amoxicillin/clavulanic acid after surgical drainage of perianal abscess in the prevention of the development of anal fistula (PERIQxA study): Study protocol for a multicenter randomized, double-blind clinical trial. Trials. 2024;25:122. DOI: 10.1186/s13063-024-07922-3
- Alam AA, Fathallah N, Aubert M, Benfredj P, Pommaret E, de Parades V. Does antibiotic therapy for anal abscess reduce the risk of fistula surgery? A retrospective study. J Visc Surg. 2025;49(9):102706. DOI: 10.1016/j.clinre.2025.102706
- Crook DL, Padfield O. A systematic review and meta-analysis of the use of packing in the management of perianal abscesses. Ann R Coll Surg Engl. 2025;107(1):29–34. DOI: 10.1308/rcsann.2023.0108
- Kim DR, Verhoeff K, Jogiat U, Miles A, Kung JY, Mocanu V. Role of prolonged packing in postoperative anorectal abscess management: A systematic review and meta-analysis. Can J Surg. 2024;67(5):E329–36. DOI: 10.1503/cjs.008423
- Skovgaards DM, Perregaard H, Dibbern CB, Nordholm-Carstensen A. Fistula development after anal abscess drainage – a multicentre retrospective cohort study. Int J Colorectal Dis. 2024;39:4. DOI: 10.1007/s00384-023-04576-6
- Ali OH, Hamza AA. Risk factors for fistula-in-ano development following perianal abscess drainage: A prospective study from Omdurman Teaching Hospital, Sudan. Rawal Med J. 2025;50(1):128–31. DOI: 10.5455/rmj.20240905061853
- Supatrakul E, Thunyacharoen S, Sanmae S, Sutharat P. Predictive factors and timing of developing anal fistula after drainage of cryptoglandular anorectal abscess: A retrospective cohort study. J Med Assoc Thai. 2024;107(5):292–9. DOI: 10.35755/jmedassocthai.2024.5.13979
- Adamina M, Minozzi S, Warusavitarne J, Buskens CJ, Chaparro M, Verstockt B, et al. ECCO guidelines on therapeutics in Crohn’s disease: Surgical treatment. J Crohns Colitis. 2024;18(10):1556–82. DOI: 10.1093/ecco-jcc/jjae089
- Lee JJ, Lightner AL. Management and treatment of perianal fistulizing Crohn’s disease. Clin Exp Gastroenterol. 2025;18:291–303. DOI: 10.2147/CEG.S528149
- Zeng X, Wang H, Deng Y, Deng Z, Bi W, Fu H. Causal relationship between obesity and anorectal abscess: A Mendelian randomization study. Front Med. 2024;11:1437849. DOI: 10.3389/fmed.2024.1437849
- Ye S, Huang Z, Zheng L, Shi Y, Zhi C, Liu N, et al. Restricted cubic spline model analysis of the association between anal fistula and anorectal abscess incidence and body mass index. Front Surg. 2024;10:1329557. DOI: 10.3389/fsurg.2023.1329557